Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas

Aggressive double- and triple-hit (DH/TH) diffuse large B-cell lymphomas (DLBCLs) feature activation of Hsp90 stress pathways. Herein, we show that Hsp90 controls posttranscriptional dynamics of key messenger RNA (mRNA) species including those encoding BCL6, MYC, and BCL2. Using a proteomics approac...

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Dades bibliogràfiques
Publicat a:Blood
Autors principals: Culjkovic-Kraljacic, Biljana, Fernando, Tharu M., Marullo, Rossella, Calvo-Vidal, Nieves, Verma, Akanksha, Yang, ShaoNing, Tabbò, Fabrizio, Gaudiano, Marcello, Zahreddine, Hiba, Goldstein, Rebecca L., Patel, Jayeshkumar, Taldone, Tony, Chiosis, Gabriela, Ladetto, Marco, Ghione, Paola, Machiorlatti, Rodolfo, Elemento, Olivier, Inghirami, Giorgio, Melnick, Ari, Borden, Katherine L. B., Cerchietti, Leandro
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2016
Matèries:
Lymphoid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4760090/
https://ncbi.nlm.nih.gov/pubmed/26603836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-05-645069
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