Prolonged pemetrexed pretreatment augments persistence of cisplatin-induced DNA damage and eliminates resistant lung cancer stem-like cells associated with EMT

BACKGROUND: Lung cancer is the leading cause of cancer-related mortality, and new therapeutic options are urgently needed. Non-small cell lung cancer (NSCLC) accounts for approximately 85 % of all lung cancers, with the current standard regimen of care for NSCLC including chemotherapy with pemetrexe...

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Veröffentlicht in:BMC Cancer
Hauptverfasser: Tièche, Colin Charles, Peng, Ren-Wang, Dorn, Patrick, Froment, Laurène, Schmid, Ralph Alexander, Marti, Thomas Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759918/
https://ncbi.nlm.nih.gov/pubmed/26895954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2117-4
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