Schedule-dependent increased efficiency of pemetrexed-ionizing radiation combination therapy elicits a differential DNA damage response in lung cancer cells

BACKGROUND: Lung cancer causes the most cancer deaths worldwide, thus there is a urgent need to develop new treatment options. Concurrent chemoradiotherapy has become a common strategy for the treatment of non-resectable solid tumors including non-small cell lung cancer. Pemetrexed is a folic acid a...

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Publicat a:Cancer Cell Int
Autors principals: Dorn, Patrick, Tièche, Colin Charles, Peng, Ren-Wang, Froment, Laurène, Schmid, Ralph Alexander, Marti, Thomas Michael
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2016
Matèries:
Primary Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010745/
https://ncbi.nlm.nih.gov/pubmed/27594806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-016-0346-x
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