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Quantitative prediction and clinical evaluation of an unexplored herb–drug interaction mechanism in healthy volunteers

Quantitative prediction of herb–drug interaction risk remains challenging. A quantitative framework to assess a potential interaction was used to evaluate a mechanism not previously tested in humans. The semipurified milk thistle product, silibinin, was selected as an exemplar herbal product inhibit...

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Detalhes bibliográficos
Publicado no:CPT Pharmacometrics Syst Pharmacol
Main Authors: Gufford, BT, Barr, JT, González‐Pérez, V, Layton, ME, White, JR, Oberlies, NH, Paine, MF
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759704/
https://ncbi.nlm.nih.gov/pubmed/26904384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12047
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