Physiologically Based Pharmacokinetic Modeling Framework for Quantitative Prediction of an Herb–Drug Interaction

Herb–drug interaction predictions remain challenging. Physiologically based pharmacokinetic (PBPK) modeling was used to improve prediction accuracy of potential herb–drug interactions using the semipurified milk thistle preparation, silibinin, as an exemplar herbal product. Interactions between sili...

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Detalhes bibliográficos
Main Authors: Brantley, S J, Gufford, B T, Dua, R, Fediuk, D J, Graf, T N, Scarlett, Y V, Frederick, K S, Fisher, M B, Oberlies, N H, Paine, M F
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4042458/
https://ncbi.nlm.nih.gov/pubmed/24670388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2013.69
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