Atheroprotection through SYK inhibition fails in established disease when local macrophage proliferation dominates lesion progression

Macrophages in the arterial intima sustain chronic inflammation during atherogenesis. Under hypercholesterolemic conditions murine Ly6C(high) monocytes surge in the blood and spleen, infiltrate nascent atherosclerotic plaques, and differentiate into macrophages that proliferate locally as disease pr...

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Détails bibliographiques
Publié dans:Basic Res Cardiol
Auteurs principaux: Lindau, Alexandra, Härdtner, Carmen, Hergeth, Sonja P., Blanz, Kelly Daryll, Dufner, Bianca, Hoppe, Natalie, Anto-Michel, Nathaly, Kornemann, Jan, Zou, Jiadai, Gerhardt, Louisa M. S., Heidt, Timo, Willecke, Florian, Geis, Serjosha, Stachon, Peter, Wolf, Dennis, Libby, Peter, Swirski, Filip K., Robbins, Clinton S., McPheat, William, Hawley, Shaun, Braddock, Martin, Gilsbach, Ralf, Hein, Lutz, von zur Mühlen, Constantin, Bode, Christoph, Zirlik, Andreas, Hilgendorf, Ingo
Format: Artigo
Langue:Inglês
Publié: Springer Berlin Heidelberg 2016
Sujets:
Original Contribution
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759214/
https://ncbi.nlm.nih.gov/pubmed/26891724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-016-0535-8
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