Atheroprotection through SYK inhibition fails in established disease when local macrophage proliferation dominates lesion progression

Macrophages in the arterial intima sustain chronic inflammation during atherogenesis. Under hypercholesterolemic conditions murine Ly6C(high) monocytes surge in the blood and spleen, infiltrate nascent atherosclerotic plaques, and differentiate into macrophages that proliferate locally as disease pr...

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Publicado en:Basic Res Cardiol
Autores principales: Lindau, Alexandra, Härdtner, Carmen, Hergeth, Sonja P., Blanz, Kelly Daryll, Dufner, Bianca, Hoppe, Natalie, Anto-Michel, Nathaly, Kornemann, Jan, Zou, Jiadai, Gerhardt, Louisa M. S., Heidt, Timo, Willecke, Florian, Geis, Serjosha, Stachon, Peter, Wolf, Dennis, Libby, Peter, Swirski, Filip K., Robbins, Clinton S., McPheat, William, Hawley, Shaun, Braddock, Martin, Gilsbach, Ralf, Hein, Lutz, von zur Mühlen, Constantin, Bode, Christoph, Zirlik, Andreas, Hilgendorf, Ingo
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer Berlin Heidelberg 2016
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Original Contribution
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759214/
https://ncbi.nlm.nih.gov/pubmed/26891724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-016-0535-8
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