The common variant of cystic fibrosis transmembrane conductance regulator is recognized by hsp70 and degraded in a pre-Golgi nonlysosomal compartment.

The most common cause of cystic fibrosis is deletion of Phe-508 (delta F508) from the cystic fibrosis transmembrane conductance regulator (CFTR). Previous studies have suggested that delta F508 CFTR is an unstable protein that retains a pattern of glycosylation specific to the endoplasmic reticulum....

Full description

Saved in:
Bibliographic Details
Main Authors: Yang, Y, Janich, S, Cohn, J A, Wilson, J M
Format: Artigo
Language:Inglês
Published: 1993
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC47592/
https://ncbi.nlm.nih.gov/pubmed/7692448
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items