The common variant of cystic fibrosis transmembrane conductance regulator is recognized by hsp70 and degraded in a pre-Golgi nonlysosomal compartment.

The most common cause of cystic fibrosis is deletion of Phe-508 (delta F508) from the cystic fibrosis transmembrane conductance regulator (CFTR). Previous studies have suggested that delta F508 CFTR is an unstable protein that retains a pattern of glycosylation specific to the endoplasmic reticulum....

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Bibliografske podrobnosti

izdano v:	Proc Natl Acad Sci U S A
Principais autores:	Yang, Y, Janich, S, Cohn, J A, Wilson, J M
Format:	Artigo
Jezik:	Inglês
Izdano:	National Academy of Sciences 1993
Teme:	Research Article
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47592/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7692448/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.20.9480
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