APOE and BDNF polymorphisms moderate amyloid β-related cognitive decline in preclinical Alzheimer's disease

Accumulation of β-amyloid (Aβ) in the brain is associated with memory decline in healthy individuals as a prelude to Alzheimer's disease (AD). Genetic factors may moderate this decline. We examined the role of apolipoprotein E (ɛ4 carrier[ɛ4(+)], ɛ4 non-carrier[ɛ4(−)]) and brain-derived neurotr...

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Detalhes bibliográficos
Publicado no:Mol Psychiatry
Main Authors: Lim, Y Y, Villemagne, V L, Laws, S M, Pietrzak, R H, Snyder, P J, Ames, D, Ellis, K A, Harrington, K, Rembach, A, Martins, R N, Rowe, C C, Masters, C L, Maruff, P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4759101/
https://ncbi.nlm.nih.gov/pubmed/25288138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2014.123
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