Deficiency of the 15-kDa selenoprotein led to cytoskeleton remodeling and non-apoptotic membrane blebbing through a RhoA/ROCK pathway

The 15-kDa selenoprotein (Sep15) has been implicated in etiology of some types of cancer. Herein, inducible RNAi cell lines were established and cell morphology and motility were analyzed. The majority of Sep15-deficient cells (>95%) formed membrane blebs in a dynamic manner. Blebbing cells trans...

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Pubblicato in:Biochem Biophys Res Commun
Autori principali: Bang, Jeyoung, Jang, Mihyun, Huh, Jang Hoe, Na, Ji-Woon, Shim, Myoungsup, Carlson, Bradley A, Tobe, Ryuta, Tsuji, Petra A., Gladyshev, Vadim N, Hatfield, Dolph L, Lee, Byeong Jae
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4758352/
https://ncbi.nlm.nih.gov/pubmed/25529450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2014.12.059
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