Deficiency of the 15-kDa selenoprotein led to cytoskeleton remodeling and non-apoptotic membrane blebbing through a RhoA/ROCK pathway

The 15-kDa selenoprotein (Sep15) has been implicated in etiology of some types of cancer. Herein, inducible RNAi cell lines were established and cell morphology and motility were analyzed. The majority of Sep15-deficient cells (>95%) formed membrane blebs in a dynamic manner. Blebbing cells trans...

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Publicado no:Biochem Biophys Res Commun
Main Authors: Bang, Jeyoung, Jang, Mihyun, Huh, Jang Hoe, Na, Ji-Woon, Shim, Myoungsup, Carlson, Bradley A, Tobe, Ryuta, Tsuji, Petra A., Gladyshev, Vadim N, Hatfield, Dolph L, Lee, Byeong Jae
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4758352/
https://ncbi.nlm.nih.gov/pubmed/25529450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2014.12.059
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