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Site-specific protein modification using lipoic acid ligase and bis-aryl hydrazone formation
A screen of Trp37 mutants of E. coli lipoic acid ligase (LplA) produced enzymes capable of ligating an aryl-aldehyde or an aryl-hydrazine substrate to LplA’s 13-amino acid acceptor peptide (LAP). Once site-specifically attached to recombinant proteins, aryl-aldehydes could be chemo-selectively deriv...
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| Publié dans: | Chembiochem |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4758125/ https://ncbi.nlm.nih.gov/pubmed/22492621 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201100764 |
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