The impact of low-frequency and rare variants on lipid levels

Using a genome-wide screen of 9.6 million genetic variants achieved through 1000 Genomes imputation in 62,166 samples, we identify association to lipids in 93 loci including 79 previously identified loci with new lead-SNPs, 10 new loci, 15 loci with a low-frequency and 10 loci with missense lead-SNP...

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מידע ביבליוגרפי
הוצא לאור ב:Nat Genet
Main Authors: Surakka, Ida, Horikoshi, Momoko, Mägi, Reedik, Sarin, Antti-Pekka, Mahajan, Anubha, Lagou, Vasiliki, Marullo, Letizia, Ferreira, Teresa, Miraglio, Benjamin, Timonen, Sanna, Kettunen, Johannes, Pirinen, Matti, Karjalainen, Juha, Thorleifsson, Gudmar, Hägg, Sara, Hottenga, Jouke-Jan, Isaacs, Aaron, Ladenvall, Claes, Beekman, Marian, Esko, Tõnu, Ried, Janina S, Nelson, Christopher P, Willenborg, Christina, Gustafsson, Stefan, Westra, Harm-Jan, Blades, Matthew, de Craen, Anton JM, de Geus, Eco J, Deelen, Joris, Grallert, Harald, Hamsten, Anders, Havulinna, Aki S., Hengstenberg, Christian, Houwing-Duistermaat, Jeanine J, Hyppönen, Elina, Karssen, Lennart C, Lehtimäki, Terho, Lyssenko, Valeriya, Magnusson, Patrik KE, Mihailov, Evelin, Müller-Nurasyid, Martina, Mpindi, John-Patrick, Pedersen, Nancy L, Penninx, Brenda WJH, Perola, Markus, Pers, Tune H, Peters, Annette, Rung, Johan, Smit, Johannes H, Steinthorsdottir, Valgerdur, Tobin, Martin D, Tsernikova, Natalia, van Leeuwen, Elisabeth M, Viikari, Jorma S, Willems, Sara M, Willemsen, Gonneke, Schunkert, Heribert, Erdmann, Jeanette, Samani, Nilesh J, Kaprio, Jaakko, Lind, Lars, Gieger, Christian, Metspalu, Andres, Slagboom, P Eline, Groop, Leif, van Duijn, Cornelia M, Eriksson, Johan G, Jula, Antti, Salomaa, Veikko, Boomsma, Dorret I, Power, Christine, Raitakari, Olli T, Ingelsson, Erik, Järvelin, Marjo-Riitta, Stefansson, Kari, Franke, Lude, Ikonen, Elina, Kallioniemi, Olli, Pietiäinen, Vilja, Lindgren, Cecilia M, Thorsteinsdottir, Unnur, Palotie, Aarno, McCarthy, Mark I, Morris, Andrew P, Prokopenko, Inga, Ripatti, Samuli
פורמט: Artigo
שפה:Inglês
יצא לאור: 2015
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4757735/
https://ncbi.nlm.nih.gov/pubmed/25961943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3300
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