Chromosome X-Wide Association Study Identifies Loci for Fasting Insulin and Height and Evidence for Incomplete Dosage Compensation

The X chromosome (chrX) represents one potential source for the “missing heritability” for complex phenotypes, which thus far has remained underanalyzed in genome-wide association studies (GWAS). Here we demonstrate the benefits of including chrX in GWAS by assessing the contribution of 404,862 chrX...

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Main Authors: Tukiainen, Taru, Pirinen, Matti, Sarin, Antti-Pekka, Ladenvall, Claes, Kettunen, Johannes, Lehtimäki, Terho, Lokki, Marja-Liisa, Perola, Markus, Sinisalo, Juha, Vlachopoulou, Efthymia, Eriksson, Johan G., Groop, Leif, Jula, Antti, Järvelin, Marjo-Riitta, Raitakari, Olli T., Salomaa, Veikko, Ripatti, Samuli
格式: Artigo
語言:Inglês
出版: Public Library of Science 2014
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916240/
https://ncbi.nlm.nih.gov/pubmed/24516404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004127
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