Modular Synthetic Inverters from Zinc Finger Proteins and Small RNAs

Synthetic zinc finger proteins (ZFPs) can be created to target promoter DNA sequences, repressing transcription. The binding of small RNA (sRNA) to ZFP mRNA creates an ultrasensitive response to generate higher effective Hill coefficients. Here we combined three “off the shelf” ZFPs and three sRNAs...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Hsia, Justin, Holtz, William J., Maharbiz, Michel M., Arcak, Murat, Keasling, Jay D.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2016
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4757538/
https://ncbi.nlm.nih.gov/pubmed/26886888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149483
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