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Targeted single molecule mutation detection with massively parallel sequencing

Next-generation sequencing (NGS) technologies have transformed genomic research and have the potential to revolutionize clinical medicine. However, the background error rates of sequencing instruments and limitations in targeted read coverage have precluded the detection of rare DNA sequence variant...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Gregory, Mark T., Bertout, Jessica A., Ericson, Nolan G., Taylor, Sean D., Mukherjee, Rithun, Robins, Harlan S., Drescher, Charles W., Bielas, Jason H.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4756847/
https://ncbi.nlm.nih.gov/pubmed/26384417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv915
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