Targeted single molecule mutation detection with massively parallel sequencing

Next-generation sequencing (NGS) technologies have transformed genomic research and have the potential to revolutionize clinical medicine. However, the background error rates of sequencing instruments and limitations in targeted read coverage have precluded the detection of rare DNA sequence variant...

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發表在:Nucleic Acids Res
Main Authors: Gregory, Mark T., Bertout, Jessica A., Ericson, Nolan G., Taylor, Sean D., Mukherjee, Rithun, Robins, Harlan S., Drescher, Charles W., Bielas, Jason H.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2016
主題:
Methods Online
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4756847/
https://ncbi.nlm.nih.gov/pubmed/26384417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv915
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