RORα switches transcriptional mode of ERRγ that results in transcriptional repression of CYP2E1 under ethanol-exposure

Increased cytochrome P450 2E1 (CYP2E1) expression is the main cause of oxidative stress, which exacerbates alcoholic liver diseases (ALDs). Estrogen-related receptor gamma (ERRγ) induces CYP2E1 expression and contributes to enhancing alcohol-induced liver injury. Retinoic acid-related orphan recepto...

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Bibliographische Detailangaben
Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Han, Yong-Hyun, Kim, Don-Kyu, Na, Tae-Young, Ka, Na-Lee, Choi, Hueng-Sik, Lee, Mi-Ock
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2016
Schlagworte:
Gene regulation, Chromatin and Epigenetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4756810/
https://ncbi.nlm.nih.gov/pubmed/26464440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1034
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