A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells

Embryonic stem cells (ESCs) represent a transient biological state, where pluripotency is coupled with fast proliferation. ESCs display a constitutively active DNA damage response (DDR), but its molecular determinants have remained elusive. Here we show in cultured ESCs and mouse embryos that H2AX p...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Ahuja, Akshay K., Jodkowska, Karolina, Teloni, Federico, Bizard, Anna H., Zellweger, Ralph, Herrador, Raquel, Ortega, Sagrario, Hickson, Ian D., Altmeyer, Matthias, Mendez, Juan, Lopes, Massimo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4756311/
https://ncbi.nlm.nih.gov/pubmed/26876348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10660
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