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Identification of an “Exceptional Responder” Cell Line to MEK1 Inhibition: Clinical Implications for MEK-targeted Therapy

The identification of somatic genetic alterations that confer sensitivity to pharmacologic inhibitors has led to new cancer therapies. To identify mutations that confer an exceptional dependency, shRNA-based loss-of-function data were analyzed from a dataset of numerous cell lines to reveal genes th...

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書誌詳細
出版年:Mol Cancer Res
主要な著者: Gannon, Hugh S., Kaplan, Nathan, Tsherniak, Aviad, Vazquez, Francisca, Weir, Barbara A., Hahn, William C., Meyerson, Matthew
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755909/
https://ncbi.nlm.nih.gov/pubmed/26582713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-15-0321
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