The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain

GPIHBP1 is a glycolipid-anchored membrane protein of capillary endothelial cells that binds lipoprotein lipase (LPL) within the interstitial space and shuttles it to the capillary lumen. The LPL•GPIHBP1 complex is responsible for margination of triglyceride-rich lipoproteins along capillaries and th...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:eLife
Egile Nagusiak: Mysling, Simon, Kristensen, Kristian Kølby, Larsson, Mikael, Beigneux, Anne P, Gårdsvoll, Henrik, Fong, Loren G, Bensadouen, André, Jørgensen, Thomas JD, Young, Stephen G, Ploug, Michael
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: eLife Sciences Publications, Ltd 2016
Gaiak:
Biophysics and Structural Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755760/
https://ncbi.nlm.nih.gov/pubmed/26725083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.12095
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