The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain

GPIHBP1 is a glycolipid-anchored membrane protein of capillary endothelial cells that binds lipoprotein lipase (LPL) within the interstitial space and shuttles it to the capillary lumen. The LPL•GPIHBP1 complex is responsible for margination of triglyceride-rich lipoproteins along capillaries and th...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:eLife
Main Authors: Mysling, Simon, Kristensen, Kristian Kølby, Larsson, Mikael, Beigneux, Anne P, Gårdsvoll, Henrik, Fong, Loren G, Bensadouen, André, Jørgensen, Thomas JD, Young, Stephen G, Ploug, Michael
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2016
Assuntos:
Biophysics and Structural Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755760/
https://ncbi.nlm.nih.gov/pubmed/26725083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.12095
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares