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Homozygosity mapping and whole-genome sequencing reveals a deep intronic PROM1 mutation causing cone–rod dystrophy by pseudoexon activation

Several genes have been implicated in the autosomal recessive form of cone–rod dystrophy (CRD), but the majority of cases remain unsolved. We identified a homozygous interval comprising two known genes associated with the autosomal recessive form of CRD, namely RAB28 and PROM1, in a consanguineous f...

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Detalhes bibliográficos
Publicado no:Eur J Hum Genet
Main Authors: Mayer, Anja K, Rohrschneider, Klaus, Strom, Tim M, Glöckle, Nicola, Kohl, Susanne, Wissinger, Bernd, Weisschuh, Nicole
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755378/
https://ncbi.nlm.nih.gov/pubmed/26153215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2015.144
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