Cloning, sequence determination, and regulation of the ribonucleotide reductase subunits from Plasmodium falciparum: a target for antimalarial therapy.

Malaria remains a leading cause of morbidity and mortality worldwide, accounting for more than one million deaths annually. We have focused on the reduction of ribonucleotides to 2'-deoxyribonucleotides, catalyzed by ribonucleotide reductase, which represents the rate-determining step in DNA replica...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Rubin, H, Salem, J S, Li, L S, Yang, F D, Mama, S, Wang, Z M, Fisher, A, Hamann, C S, Cooperman, B S
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47551/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8415692/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.20.9280
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