Cloning, sequence determination, and regulation of the ribonucleotide reductase subunits from Plasmodium falciparum: a target for antimalarial therapy.

Malaria remains a leading cause of morbidity and mortality worldwide, accounting for more than one million deaths annually. We have focused on the reduction of ribonucleotides to 2'-deoxyribonucleotides, catalyzed by ribonucleotide reductase, which represents the rate-determining step in DNA re...

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Detalhes bibliográficos
Main Authors: Rubin, H, Salem, J S, Li, L S, Yang, F D, Mama, S, Wang, Z M, Fisher, A, Hamann, C S, Cooperman, B S
Formato: Artigo
Idioma:Inglês
Publicado em: 1993
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC47551/
https://ncbi.nlm.nih.gov/pubmed/8415692
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