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Cloning, sequence determination, and regulation of the ribonucleotide reductase subunits from Plasmodium falciparum: a target for antimalarial therapy.

Malaria remains a leading cause of morbidity and mortality worldwide, accounting for more than one million deaths annually. We have focused on the reduction of ribonucleotides to 2'-deoxyribonucleotides, catalyzed by ribonucleotide reductase, which represents the rate-determining step in DNA replica...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Rubin, H, Salem, J S, Li, L S, Yang, F D, Mama, S, Wang, Z M, Fisher, A, Hamann, C S, Cooperman, B S
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47551/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8415692/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.20.9280
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