Toll-like receptor agonist therapy can profoundly augment the antitumor activity of adoptively transferred CD8(+) T cells without host preconditioning

BACKGROUND: Lymphodepletion enhances adoptive T cell transfer (ACT) therapy by activating the innate immune system via microbes released from the radiation-injured gut. Microbial components, such as LPS, are key mediators of total body irradiation (TBI) enhancement, but our ability to strategically...

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Publicat a:J Immunother Cancer
Autors principals: Nelson, Michelle H., Bowers, Jacob S., Bailey, Stefanie R., Diven, Marshall A., Fugle, Caroline W., Kaiser, Andrew D. M., Wrzesinski, Claudia, Liu, Bei, Restifo, Nicholas P., Paulos, Chrystal M.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754841/
https://ncbi.nlm.nih.gov/pubmed/26885368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-016-0110-8
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