Grapefruit-derived Nanovectors Delivering Therapeutic miR17 Through an Intranasal Route Inhibit Brain Tumor Progression

The lack of access to the brain is a major obstacle for central nervous system drug development. In this study, we demonstrate the capability of a grapefruit-derived nanovector (GNV) to carry miR17 for therapeutic treatment of mouse brain tumor. We show that GNVs coated with folic acid (FA-GNVs) are...

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Bibliographic Details
Published in:Mol Ther
Main Authors: Zhuang, Xiaoying, Teng, Yun, Samykutty, Abhilash, Mu, Jingyao, Deng, Zhongbin, Zhang, Lifeng, Cao, Pengxiao, Rong, Yuan, Yan, Jun, Miller, Donald, Zhang, Huang-Ge
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754550/
https://ncbi.nlm.nih.gov/pubmed/26444082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.188
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