Oral-tolerization Prevents Immune Responses and Improves Transgene Persistence Following Gene Transfer Mediated by Adeno-associated Viral Vector

Gene therapy represents a feasible strategy to treat inherited monogenic diseases and intramuscular (i.m.) injection of recombinant adeno-associated viral (AAV) vector is now recognized as a convenient and safe method of gene transfer. However, this approach is hampered by immune responses directed...

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Publicado en:Mol Ther
Autores principales: Hardet, Romain, Chevalier, Benjamin, Dupaty, Léa, Naïmi, Yassine, Riou, Gaëtan, Drouot, Laurent, Jean, Laetitia, Salvetti, Anna, Boyer, Olivier, Adriouch, Sahil
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754539/
https://ncbi.nlm.nih.gov/pubmed/26265250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2015.146
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