Estimating Effect Sizes and Expected Replication Probabilities from GWAS Summary Statistics

Genome-wide Association Studies (GWAS) result in millions of summary statistics (“z-scores”) for single nucleotide polymorphism (SNP) associations with phenotypes. These rich datasets afford deep insights into the nature and extent of genetic contributions to complex phenotypes such as psychiatric d...

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Publicat a:Front Genet
Autors principals: Holland, Dominic, Wang, Yunpeng, Thompson, Wesley K., Schork, Andrew, Chen, Chi-Hua, Lo, Min-Tzu, Witoelar, Aree, Werge, Thomas, O'Donovan, Michael, Andreassen, Ole A., Dale, Anders M.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2016
Matèries:
Genetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754432/
https://ncbi.nlm.nih.gov/pubmed/26909100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2016.00015
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