Leveraging Genomic Annotations and Pleiotropic Enrichment for Improved Replication Rates in Schizophrenia GWAS

Most of the genetic architecture of schizophrenia (SCZ) has not yet been identified. Here, we apply a novel statistical algorithm called Covariate-Modulated Mixture Modeling (CM3), which incorporates auxiliary information (heterozygosity, total linkage disequilibrium, genomic annotations, pleiotropy...

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Bibliografiske detaljer
Udgivet i:PLoS Genet
Main Authors: Wang, Yunpeng, Thompson, Wesley K., Schork, Andrew J., Holland, Dominic, Chen, Chi-Hua, Bettella, Francesco, Desikan, Rahul S., Li, Wen, Witoelar, Aree, Zuber, Verena, Devor, Anna, Nöthen, Markus M., Rietschel, Marcella, Chen, Qiang, Werge, Thomas, Cichon, Sven, Weinberger, Daniel R., Djurovic, Srdjan, O’Donovan, Michael, Visscher, Peter M., Andreassen, Ole A., Dale, Anders M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4726519/
https://ncbi.nlm.nih.gov/pubmed/26808560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005803
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