Leveraging Genomic Annotations and Pleiotropic Enrichment for Improved Replication Rates in Schizophrenia GWAS

Most of the genetic architecture of schizophrenia (SCZ) has not yet been identified. Here, we apply a novel statistical algorithm called Covariate-Modulated Mixture Modeling (CM3), which incorporates auxiliary information (heterozygosity, total linkage disequilibrium, genomic annotations, pleiotropy...

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Detaylı Bibliyografya
Yayımlandı:PLoS Genet
Asıl Yazarlar: Wang, Yunpeng, Thompson, Wesley K., Schork, Andrew J., Holland, Dominic, Chen, Chi-Hua, Bettella, Francesco, Desikan, Rahul S., Li, Wen, Witoelar, Aree, Zuber, Verena, Devor, Anna, Nöthen, Markus M., Rietschel, Marcella, Chen, Qiang, Werge, Thomas, Cichon, Sven, Weinberger, Daniel R., Djurovic, Srdjan, O’Donovan, Michael, Visscher, Peter M., Andreassen, Ole A., Dale, Anders M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2016
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4726519/
https://ncbi.nlm.nih.gov/pubmed/26808560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005803
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