SCF(Fbxo22)-KDM4A targets methylated p53 for degradation and regulates senescence

Recent evidence has revealed that senescence induction requires fine-tuned activation of p53, however, mechanisms underlying the regulation of p53 activity during senescence have not as yet been clearly established. We demonstrate here that SCF(Fbxo22)-KDM4A is a senescence-associated E3 ligase targ...

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Pubblicato in:Nat Commun
Autori principali: Johmura, Yoshikazu, Sun, Jia, Kitagawa, Kyoko, Nakanishi, Keiko, Kuno, Toshiya, Naiki-Ito, Aya, Sawada, Yumi, Miyamoto, Tomomi, Okabe, Atsushi, Aburatani, Hiroyuki, Li, ShengFan, Miyoshi, Ichiro, Takahashi, Satoru, Kitagawa, Masatoshi, Nakanishi, Makoto
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754341/
https://ncbi.nlm.nih.gov/pubmed/26868148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10574
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