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SCF(Fbxo22)-KDM4A targets methylated p53 for degradation and regulates senescence
Recent evidence has revealed that senescence induction requires fine-tuned activation of p53, however, mechanisms underlying the regulation of p53 activity during senescence have not as yet been clearly established. We demonstrate here that SCF(Fbxo22)-KDM4A is a senescence-associated E3 ligase targ...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4754341/ https://ncbi.nlm.nih.gov/pubmed/26868148 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10574 |
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