The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient-induced Lysine Acetylation of Mitochondrial Proteins

Lysine acetylation (AcK), a posttranslational modification wherein a two-carbon acetyl group binds covalently to a lysine residue, occurs prominently on mitochondrial proteins and has been linked to metabolic dysfunction. An emergent theory suggests mitochondrial AcK occurs via mass action rather th...

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Udgivet i:Cell Rep
Main Authors: Davies, Michael N., Kjalarsdottir, Lilja, Thompson, J. Will, Dubois, Laura G., Stevens, Robert D., Ilkayeva, Olga R., Brosnan, M. Julia, Rolph, Timothy P., Grimsrud, Paul A., Muoio, Deborah M.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754083/
https://ncbi.nlm.nih.gov/pubmed/26748706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.12.030
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