LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function

Mutations in leucine-rich repeat kinase 2 (LRRK2) lead to late-onset, autosomal dominant Parkinson's disease, characterized by the degeneration of dopamine neurons of the substantia nigra pars compacta, a deficit in dopamine neurotransmission and the development of motor and non-motor symptoms....

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Sloan, Max, Alegre-Abarrategui, Javier, Potgieter, Dawid, Kaufmann, Anna-Kristin, Exley, Richard, Deltheil, Thierry, Threlfell, Sarah, Connor-Robson, Natalie, Brimblecombe, Katherine, Wallings, Rebecca, Cioroch, Milena, Bannerman, David M., Bolam, J. Paul, Magill, Peter J., Cragg, Stephanie J., Dodson, Paul D., Wade-Martins, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754049/
https://ncbi.nlm.nih.gov/pubmed/26744332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv628
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