Homozygous mutation of PLCZ1 leads to defective human oocyte activation and infertility that is not rescued by the WW-binding protein PAWP

In mammals, sperm–oocyte fusion initiates Ca(2+) oscillations leading to a series of events called oocyte activation, which is the first stage of embryo development. Ca(2+) signaling is elicited by the delivery of an oocyte-activating factor by the sperm. A sperm-specific phospholipase C (PLCZ1) has...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Escoffier, Jessica, Lee, Hoi Chang, Yassine, Sandra, Zouari, Raoudha, Martinez, Guillaume, Karaouzène, Thomas, Coutton, Charles, Kherraf, Zine-eddine, Halouani, Lazhar, Triki, Chema, Nef, Serge, Thierry-Mieg, Nicolas, Savinov, Sergey N., Fissore, Rafael, Ray, Pierre F., Arnoult, Christophe
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754041/
https://ncbi.nlm.nih.gov/pubmed/26721930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv617
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