Dpy19l2-deficient globozoospermic sperm display altered genome packaging and DNA damage that compromises the initiation of embryo development

We recently identified the DPY19L2 gene as the main genetic cause of human globozoospermia. Non-genetically characterized cases of globozoospermia were associated with DNA alterations, suggesting that DPY19L2-dependent globozoospermia may be associated with poor DNA quality. However the origins of s...

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Gepubliceerd in:Mol Hum Reprod
Hoofdauteurs: Yassine, Sandra, Escoffier, Jessica, Martinez, Guillaume, Coutton, Charles, Karaouzène, Thomas, Zouari, Raoudha, Ravanat, Jean-Luc, Metzler-Guillemain, Catherine, Lee, Hoi Chang, Fissore, Rafael, Hennebicq, Sylviane, Ray, Pierre F., Arnoult, Christophe
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2015
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Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4311149/
https://ncbi.nlm.nih.gov/pubmed/25354700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molehr/gau099
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