Heme oxygenase-1 attenuates IL-1β induced alteration of anabolic and catabolic activities in intervertebral disc degeneration

Intervertebral disc degeneration (IDD) is characterized by disordered extracellular matrix (ECM) metabolism, implicating subdued anabolism and enhanced catabolic activities in the nucleus pulposus (NP) of discs. Pro-inflammatory cytokines such as interleukin-1β (IL-1β) are considered to be potent me...

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Publicado en:Sci Rep
Autores principales: Hu, Bo, Shi, Changgui, Xu, Chen, Cao, Peng, Tian, Ye, Zhang, Ying, Deng, Lianfu, Chen, Huajiang, Yuan, Wen
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753421/
https://ncbi.nlm.nih.gov/pubmed/26877238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21190
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