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Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration

INTRODUCTION: The aim of this study was to compare the effects of tumour necrosis factor-alpha (TNF-α) and interleukin-1-beta (IL-1β) on protease and catabolic cytokine and receptor gene expression in normal and degenerate human nucleus pulposus cells in alginate culture. METHODS: Cells isolated fro...

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Detalhes bibliográficos
Main Authors: Millward-Sadler, S Jane, Costello, Patrick W, Freemont, Anthony J, Hoyland, Judith A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714110/
https://ncbi.nlm.nih.gov/pubmed/19435506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2693
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