Intranasal insulin protects against substantia nigra dopaminergic neuronal loss and alleviates motor deficits induced by 6-OHDA in rats

Protection of substantia nigra (SN) dompaminergic (DA) neurons by neurotrophic factors (NTF) is one of the promising strategies in Parkinson’s disease (PD) therapy. A major clinical challenge for NTF-based therapy is that NTFs need to be delivered into the brain via invasive means, which often shows...

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Pubblicato in:Neuroscience
Autori principali: Pang, Yi, Lin, Shuying, Wright, Camilla, Shen, Juying, Carter, Kathleen, Bhatt, Abhay, Fan, Lir-Wan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753102/
https://ncbi.nlm.nih.gov/pubmed/26777890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2016.01.020
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