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Degradation of phage transcripts by CRISPR-associated RNases enables type III CRISPR-Cas immunity
Type III-A CRISPR-Cas systems defend prokaryotes against viral infection using CRISPR RNA (crRNA)-guided nucleases that perform co-transcriptional cleavage of the viral target DNA and its transcripts. Whereas DNA cleavage is essential for immunity, the function of RNA targeting is unknown. Here we s...
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| Publié dans: | Cell |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4752873/ https://ncbi.nlm.nih.gov/pubmed/26853474 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.12.053 |
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