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Non-specific degradation of transcripts promotes plasmid clearance during type III-A CRISPR-Cas immunity

Type III-A CRISPR-Cas systems employ the Cas10-Csm complex to destroy bacteriophages and plasmids, using a guide RNA to locate complementary RNA molecules from the invader and trigger an immune response that eliminates the infecting DNA. In addition, these systems possess the non-specific RNase Csm6...

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Publicat a:Nat Microbiol
Autors principals: Rostøl, Jakob T., Marraffini, Luciano
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6430669/
https://ncbi.nlm.nih.gov/pubmed/30692669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-018-0353-x
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