Cryo-EM Structures of the Magnesium Channel CorA Reveal Symmetry Break Upon Gating

CorA, the major Mg2+ uptake system in prokaryotes, is gated by intracellular Mg2+ (KD ~1–2 mM). X-ray crystallographic studies of CorA show similar conformations under Mg2+-bound and Mg2+-free conditions, but EPR spectroscopic studies reveal large Mg2+-driven quaternary conformational changes. Here,...

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發表在:Cell
Main Authors: Matthies, Doreen, Dalmas, Olivier, Borgnia, Mario J., Dominik, Pawel K., Merk, Alan, Rao, Prashant, Reddy, Bharat G., Islam, Shahidul, Bartesaghi, Alberto, Perozo, Eduardo, Subramaniam, Sriram
格式: Artigo
語言:Inglês
出版: 2016
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4752722/
https://ncbi.nlm.nih.gov/pubmed/26871634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.12.055
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