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A repulsion mechanism explains magnesium permeation and selectivity in CorA

Magnesium (Mg(2+)) plays a central role in biology, regulating the activity of many enzymes and stabilizing the structure of key macromolecules. In bacteria, CorA is the primary source of Mg(2+) uptake and is self-regulated by intracellular Mg(2+). Using a gating mutant at the divalent ion binding s...

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Detalhes bibliográficos
Main Authors: Dalmas, Olivier, Sandtner, Walter, Medovoy, David, Frezza, Ludivine, Bezanilla, Francisco, Perozo, Eduardo
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3939898/
https://ncbi.nlm.nih.gov/pubmed/24516146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1319054111
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