Intact Cohesion, Anaphase, and Chromosome Segregation in Human Cells Harboring Tumor-Derived Mutations in STAG2

Somatic mutations of the cohesin complex subunit STAG2 are present in diverse tumor types. We and others have shown that STAG2 inactivation can lead to loss of sister chromatid cohesion and alterations in chromosome copy number in experimental systems. However, studies of naturally occurring human t...

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Udgivet i:PLoS Genet
Main Authors: Kim, Jung-Sik, He, Xiaoyuan, Orr, Bernardo, Wutz, Gordana, Hill, Victoria, Peters, Jan-Michael, Compton, Duane A., Waldman, Todd
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4752446/
https://ncbi.nlm.nih.gov/pubmed/26871722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005865
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