Key Role of ROS in the Process of 15-Lipoxygenase/15-Hydroxyeicosatetraenoiccid-Induced Pulmonary Vascular Remodeling in Hypoxia Pulmonary Hypertension

We previously reported that 15-lipoxygenase (15-LO) and its metabolite 15-hydroxyeicosatetraenoic acid (15-HETE) were up-regulated in pulmonary arterial cells from both pulmonary artery hypertension patients and hypoxic rats and that these factors mediated the progression of pulmonary hypertension (...

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Pubblicato in:PLoS One
Autori principali: Li, Qian, Mao, Min, Qiu, Yanli, Liu, Gaofeng, Sheng, Tingting, Yu, Xiufeng, Wang, Shuang, Zhu, Daling
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4752324/
https://ncbi.nlm.nih.gov/pubmed/26871724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149164
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