Positive Feedback-Loop of Telomerase Reverse Transcriptase and 15-Lipoxygenase-2 Promotes Pulmonary Hypertension

OBJECTIVE: Pulmonary hypertension (PH) is characterized with pulmonary vasoconstriction and vascular remodeling mediated by 15-lipoxygenase (15-LO)/15-hydroxyeicosatetraenoic acid (15-HETE) according to our previous studies. Meanwhile, telomerase reverse transcriptase (TERT) activity is highly corre...

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Autors principals: Shen, Tingting, Ma, Jun, Zhang, Lei, Yu, Xiufeng, Liu, Mengmeng, Hou, Yunlong, Wang, Yanyan, Ma, Cui, Li, Shuzhen, Zhu, Daling
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871619/
https://ncbi.nlm.nih.gov/pubmed/24376652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0083132
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