Endoplasmic reticulum and lysosomal Ca(2+) stores are remodelled in GBA1-linked Parkinson disease patient fibroblasts

Mutations in β-glucocerebrosidase (encoded by GBA1) cause Gaucher disease (GD), a lysosomal storage disorder, and increase the risk of developing Parkinson disease (PD). The pathogenetic relationship between the two disorders is unclear. Here, we characterised Ca(2+) release in fibroblasts from type...

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Publicat a:Cell Calcium
Autors principals: Kilpatrick, Bethan S., Magalhaes, Joana, Beavan, Michelle S., McNeill, Alisdair, Gegg, Matthew E., Cleeter, Michael W.J., Bloor-Young, Duncan, Churchill, Grant C., Duchen, Michael R., Schapira, Anthony H., Patel, Sandip
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4751977/
https://ncbi.nlm.nih.gov/pubmed/26691915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ceca.2015.11.002
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