Elevated Glucose Levels Promote Contractile and Cytoskeletal Gene Expression in Vascular Smooth Muscle via Rho/Protein Kinase C and Actin Polymerization

Both type 1 and type 2 diabetes are associated with increased risk of cardiovascular disease. This is in part attributed to the effects of hyperglycemia on vascular endothelial and smooth muscle cells, but the underlying mechanisms are not fully understood. In diabetic animal models, hyperglycemia r...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Hien, Tran Thi, Turczyńska, Karolina M., Dahan, Diana, Ekman, Mari, Grossi, Mario, Sjögren, Johan, Nilsson, Johan, Braun, Thomas, Boettger, Thomas, Garcia-Vaz, Eliana, Stenkula, Karin, Swärd, Karl, Gomez, Maria F., Albinsson, Sebastian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4751395/
https://ncbi.nlm.nih.gov/pubmed/26683376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.654384
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